Product Overview:
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that accumulates under low-oxygen conditions.{10948,11044} Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.{11044,9833,9834,9835,10695} HIF-1α is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities.{11043,10898} Cayman Chemical’s HIF-1α polyclonal antibody can be used for WB analysis for HIF-1α on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.