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℡ 4000-520-616
℡ 4000-520-616
Bertin Pharma/(±)9(10)-DiHOME - C18H34O4 - Bertin Bioreagent/25 µg/53400
产品编号:53400
市  场 价:¥660.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$33.00
品      牌: Bertin Pharma
公      司:Bertin Pharma
公司分类:
Bertin Pharma/(±)9(10)-DiHOME - C18H34O4 - Bertin Bioreagent/25 µg/53400
商品介绍
Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (±)9,10-dihydroxy-12Z-octadecenoic acid
Correlated keywords:
  • epoxides epoxygenase leukotoxin cytochrome P450 (+/-)9(10)-DiHOMes (+/-)9,10-DiHOMes CYP450 (±)9(10)-Dihydroxy-Octadec-12-Enoic Acid
Product Overview:
(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150
90150.1
21909) also known as leukotoxin.{8529} It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.{17057} It is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike leukotoxin, which is only toxic to cells containing sEH.{8529,17057} A mixture of 9(10)- and 12(13)-DiHOME induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice.{15651,5617} 9(10)-DiHOME is a toxic lipid mediator involved in acute respiratory distress syndrome (ARDs), a common and often fatal complication in severe burn victims.{17057,15651} Levels of 9(10)-DiHOME are increased in bronchoalveolar lavage fluid (BALF) from women, but not men, with chronic obstructive pulmonary disease (COPD).{42555} BALF levels are also increased in patients with allergic asthma following allergen exposure compared to patients without allergic asthma.{49189} It has been used as a plasma biomarker for sEH activity in vivo.{42555}
品牌介绍

Bertin Pharma


在过去的30年里,Bertin生物试剂在开发酶免疫分析试剂盒方面一直在开发一种独特的技术。


Over the past 30 years, Bertin Bioreagent has been developing a unique know-how in the development of enzyme immunoassay kits thanks to its outstanding scientific teams. This expertise is twofold: it enables the development of innovative and high quality products on biomarkers of interest and advises and accompanies our customers in their research.


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