ProductOverview:Source:humanrecombinantN-terminalHis-taggedproteinfromSf9cells•SPHK1catalyzestheproductionofsphingosine-1-phosphate,alipidmediatorwithbroadspectrumof
BIOLOGicalactivitiesincludingcellproliferation,survival,migration,cytoskeletalorganization,andmorphogenesis.
Sphingosinekinase(SPHK)isanimportantenzymeinthesphingolipidmetabolicpathway.SPHKsphosphorylateD-erythro-sphingosinetoyieldsphingosine-1-phosphate(S1P).TodatetwoisoformsofSPHK,SPHK1andSPHK2,havebeenidentified&characterizedfrommammaliancells.Amongthem,SPHK1hasbeenimplicatedtoplayaroleinsignalingpathwaysinmastcellsandinTNF-α-triggeredresponsesoffibroblastsandepithelialcells.RecentfindingsalsoindicatethatSPHK1mRNAlevelsareincreasedinavarietyofhumantumors.BraintumorswithhighSPHK1expressioncorrelatedwithpoorsurvivalofpatientsandhighexpressionofSPHK1appearstobeanoncogeniceventrequiredforerythroleukaemicprogression.ThusSPHKisapotentialtherapeutictargetforthecontrolofcancerandinflammation.
Data:
Size:25µg
Shipping:dryice
StABIlity:Storeat-80degrees;shelflife365daysmaximumafterproduction
Formulation:25mMTris-HCl,pH8.0,containing100mMsodiumchloride,0.05%Polysorbate20,50%glycerol,and3mMDTT
Purity:≥90%estimatedbySDS-PAGE
CustomCode:3507907000
UNSPSCcode:12352204
Bertin Pharma
在过去的30年里,Bertin生物试剂在开发酶免疫分析试剂盒方面一直在开发一种独特的技术。
Over the past 30 years, Bertin Bioreagent has been developing a unique know-how in the development of enzyme immunoassay kits thanks to its outstanding scientific teams. This expertise is twofold: it enables the development of innovative and high quality products on biomarkers of interest and advises and accompanies our customers in their research.
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